Rejuran Treatment in Korea: Everything You Need to Know About Salmon DNA Injections

Rejuran treatments have taken the Korean skincare world by storm, but many international patients still have questions about this revolutionary procedure. In this comprehensive guide, AB Plastic Surgery Korea's experts answer everything you've been wondering about Rejuran treatments.

1. What Is Rejuran and Why Is It So Popular in Korea?

Rejuran is an innovative skin treatment that originated in South Korea and has gained global recognition for its remarkable skin regeneration and anti-aging properties. Unlike traditional fillers or botox, Rejuran works differently:

• It contains polynucleotides (PN) extracted from salmon DNA

• These polynucleotides stimulate your skin's natural healing processes

• The treatment rebuilds and regenerates damaged skin cells

• Results in improved skin texture, elasticity, and overall quality

Rejuran has become a cornerstone treatment in Korea's advanced skincare landscape because it addresses fundamental skin health rather than simply masking signs of aging.

Why Rejuran Is Different from Typical Skin Boosters

While Rejuran is often grouped with skin boosters, it functions very differently from conventional treatments that primarily focus on hydration. Understanding this distinction is essential when deciding whether Rejuran is the right option for your skin concerns.

• PN-Based Regeneration, Not Just Hydration
  Most skin boosters use hyaluronic acid (HA) to temporarily improve skin moisture and plumpness. In contrast, Rejuran uses polynucleotides (PN) derived from salmon DNA, which actively support skin regeneration at a cellular level.

• Focus on Skin Repair and Healing
  Rejuran stimulates fibroblast activity, helping your skin repair itself by producing collagen and improving structural integrity. This makes it particularly effective for damaged, aging, or acne-prone skin.

• Gradual but Fundamental Improvement
  Unlike hydration-focused boosters that provide immediate glow, Rejuran delivers progressive improvements over several weeks. The goal is not temporary enhancement, but long-term improvement in skin quality.

• Strengthens Skin from Within
  Instead of simply adding moisture or volume, Rejuran works to restore the skin barrier, improve elasticity, and enhance overall resilience—making your skin healthier over time.

In simple terms, while traditional skin boosters are designed to hydrate and temporarily enhance the skin’s appearance, Rejuran is designed to repair, regenerate, and strengthen the skin from within. This fundamental difference is why Rejuran is often considered a regenerative treatment rather than a conventional skin booster.

Learn What to Know Before Getting Rejuran

2. Is Rejuran a Filler? Understanding the Important Differences

One of the most common misconceptions is that Rejuran is a type of dermal filler. This is not accurate.

How Rejuran differs from fillers:

Think of Rejuran as a skin quality enhancer rather than a filler—it improves your skin from within instead of adding volume.

Rejuran vs Other Skin Boosters: What’s the Difference?

Beyond fillers, many patients compare Rejuran with other popular skin boosters in Korea. While they may appear similar, each treatment works differently and targets specific skin concerns.

Key takeaway: While most skin boosters focus on hydration or temporary glow, Rejuran targets deep skin regeneration and long-term repair, making it a preferred choice for improving overall skin quality rather than just short-term enhancement.

3. Different Types of Rejuran Treatments Available in Korea

At AB Plastic Surgery Korea, we offer several specialized Rejuran formulations, each designed for specific concerns:

Rejuran Healer

• The original and most popular formulation

• Ideal for overall skin regeneration

• Best for treating fine lines, enlarged pores, and improving elasticity

• Commonly used on face, neck, and décolletage

Rejuran I

• Higher concentration of polynucleotides

• Specifically formulated for deeper wrinkles

• Enhanced regenerative properties

• Suitable for more mature skin

Rejuran S

• Specialized for scar treatment

• Helps improve acne scarring and surgical scars

• Contains additional healing components

• May be used in conjunction with other scar treatments

Rejuran Eyes

• Specifically formulated for the delicate eye area

• Addresses dark circles, fine lines, and crepey skin

• Lower concentration to suit thin under-eye skin

• Minimal swelling compared to other treatments

4. The Science Behind Rejuran: How It Transforms Your Skin

Rejuran's effectiveness is backed by significant scientific research. Here's how this innovative treatment works at a cellular level:

• DNA Regeneration: The polynucleotides in Rejuran are similar to human DNA, allowing them to integrate with your skin cells.

• Cell Proliferation: Rejuran stimulates fibroblast cells, which produce collagen and elastin—the building blocks of youthful skin.

• Improved Blood Flow: Enhanced microcirculation brings more nutrients and oxygen to skin cells.

• Strengthened Skin Barrier: Repairs and reinforces your skin's protective barrier function.

• Anti-inflammatory Effects: Reduces inflammation, a key factor in skin aging and damage.

• Increased Hydration: Improves your skin's ability to retain moisture naturally.

This multi-faceted approach is why Rejuran delivers such comprehensive skin improvements rather than just addressing a single concern.

5. Is Rejuran Painful? What to Expect During Treatment

Many prospective patients wonder about the comfort level during Rejuran treatments. Here's what to expect at AB Plastic Surgery Korea:

Before Treatment

• Topical numbing cream is applied 30-45 minutes prior to treatment

• Your skin is thoroughly cleansed and prepped

• Photos are taken for before/after comparison

During Treatment

• Most patients describe the sensation as mild pinpricks

• Our advanced techniques minimize discomfort:

• Ultra-fine needles reduce pain

• Expert injection techniques avoid sensitive areas

• Temperature-controlled product for comfortable delivery

• The entire facial treatment takes approximately 15-30 minutes

Pain Management Options

• Standard topical anesthesia (included in all treatments)

• Premium nerve block options for extremely sensitive patients

• Cooling devices during treatment to reduce discomfort

• Pro-comfort injection techniques unique to our clinic

6. Rejuran Side Effects: What's Normal and What's Not

Understanding potential side effects helps you prepare for your Rejuran treatment:

Common and Normal Effects (2-3 days)

• Small injection bumps (mosquito bite-like appearance)

• Mild redness at injection sites

• Slight swelling, particularly in thinner-skinned areas

• Temporary sensitivity to touch

Less Common Effects (1-5% of patients)

• Bruising at injection sites

• Prolonged redness (3+ days)

• Itching sensation during healing phase

Rare Complications (<1% of patients)

• Infection (prevented by strict sterile techniques)

• Allergic reactions

• Prolonged swelling or nodules

At AB Plastic Surgery Korea, our complication rate is significantly lower than the industry average due to our experienced practitioners, premium-quality products, and strict sterilization protocols.

7. How Many Rejuran Sessions Do You Need for Optimal Results?

Rejuran is not a one-and-done treatment. For optimal results, we recommend:

Initial Treatment Phase

• Standard protocol: 3 sessions spaced 4 weeks apart

• This establishes a foundation for skin regeneration

• Visible improvements typically begin after the second session

• By the third session, most patients see significant improvement in texture and elasticity

Maintenance Phase

• After completing the initial series, maintenance treatments every 6-12 months

• Younger patients (20s-30s) typically need less frequent maintenance

• Mature skin (40s+) benefits from treatments every 6 months

• Your provider will create a customized schedule based on your skin's response

Specialized Concerns

• Acne scarring may require 4-6 initial sessions for optimal improvement

• Deep wrinkles may benefit from combining Rejuran with complementary treatments

• Sun-damaged skin often requires the full series before dramatic improvements

How Long Do Rejuran Results Last?

One of the most frequently asked questions about Rejuran is how long the results actually last. Unlike treatments that provide immediate but temporary effects, Rejuran works by improving your skin over time, which influences both the timeline and longevity of results.

Typical Duration of Results

• Results typically last 6 to 12 months after completing the recommended treatment sessions

• Longevity depends on skin condition, age, and lifestyle factors

• Maintenance treatments help extend and stabilize results over time

How Results Develop Over Time

• After 1st session: Skin feels more hydrated and slightly smoother

• After 2nd session: Noticeable improvement in texture, pores, and overall tone

• After 3rd session: Significant enhancement in elasticity and skin quality

• 1–3 months later: Continued collagen production leads to more refined and stable results

Why Rejuran Lasts Longer Than Typical Skin Boosters

Unlike hyaluronic acid–based skin boosters that focus primarily on hydration, Rejuran stimulates collagen production and skin repair. This means the results are not just temporary improvements, but structural changes in your skin.

Because of this regenerative mechanism, Rejuran results tend to last longer and improve gradually over time, rather than fading quickly after treatment.

8. Rejuran Recovery: What to Expect After Treatment

One of the advantages of Rejuran is its minimal downtime, but understanding the recovery process helps set realistic expectations:

Hours 0-12

• Small bumps at injection sites (resembling mosquito bites)

• Mild redness common, especially in sensitive areas

• Apply cool compress if needed for comfort

• Avoid touching or applying pressure to treated areas

Day 1-2

• Bumps begin to subside

• Redness significantly diminishes

• Makeup can be applied (mineral-based recommended)

• Most patients return to normal activities

Day 3-5

•  Typically all visible signs of treatment resolved

• Initial improvements in skin texture may be noticeable

• Normal skincare routine can be resumed

• Sun protection remains essential

Special Recovery Instructions

• Avoid direct sun exposure for 48 hours

• No saunas, hot baths, or intense exercise for 24 hours

• Refrain from alcohol consumption for 24 hours (reduces risk of bruising)

• Hold off on exfoliants or retinoids for 3 days

9. The Results: What Improvements Can You Expect from Rejuran?

Understanding realistic outcomes helps you determine if Rejuran is right for your concerns:

Immediate Results (1-2 weeks)

• Improved skin hydration

• Subtle glow and luminosity

• Initial improvement in fine lines

Medium-Term Results (1-3 months)

• Noticeable improvement in skin texture

• Reduced pore size

• Diminished fine lines

• Enhanced skin elasticity

• Improved overall tone

Long-Term Results (3+ months)

• Significant improvement in skin quality

• Reduction in acne scarring (when applicable)

• Enhanced skin resilience

• Natural, healthy appearance

• Long-lasting skin regeneration effects

Before and After Timeline: When Will You See Results?

To better understand how Rejuran works over time, here is a simplified timeline of typical skin changes:

Note: This timeline summarizes typical progress, while detailed improvements are explained in the sections above.

What Rejuran Won't Do

• Provide immediate volume like fillers

• Replace the lifting effects of threads or surgery

• Completely eliminate deep wrinkles in a single session

• Change facial structure or features

Rejuran works best for patients seeking genuine skin quality improvements rather than dramatic structural changes.

Read a Real 3-Week Review of Ultherapy & Rejuran

10. Ideal Candidates: Is Rejuran Right for You?

Rejuran can benefit many skin types and concerns, but it's particularly effective for:

By Age Group

• 20s-30s: Preventative care, early fine lines, acne scarring, improving skin quality

• 30s-40s: Fine to moderate lines, enlarged pores, early loss of elasticity, dullness

• 50s+: Skin thinning, crepiness, moderate wrinkles, overall skin rejuvenation

By Skin Concern

• Texture issues: Uneven texture, roughness, lack of smoothness

• Aging signs: Fine lines, reduced elasticity, thinning skin

• Acne aftermath: Post-acne marks, shallow scarring, redness

• Environmental damage: Sun damage, pollution effects, stressed skin

Who Should Avoid Rejuran Treatment?

While Rejuran is generally safe and suitable for a wide range of patients, there are certain cases where the treatment may not be recommended. A proper consultation is essential to determine suitability.

Not Ideal For

• Patients seeking immediate dramatic results
  Rejuran works gradually through skin regeneration rather than providing instant lifting or volumizing effects.

• Those with severe deep wrinkles as a primary concern
  These cases may require combination treatments such as fillers or lifting procedures.

• Individuals with fish or seafood allergies
  As Rejuran is derived from salmon DNA, allergic reactions may occur.

• Active skin infections or inflammatory conditions
  Treatment should be postponed until the skin is fully healed.

Important: A personalized consultation is the most important step in determining whether Rejuran is right for you. At AB Plastic Surgery Korea, treatment plans are customized based on your skin condition and medical history.

Learn More About Rejuran Healer FAQs 

Take the Next Step with AB Plastic Surgery Korea's Premium Rejuran Experience

At AB Plastic Surgery Korea, we offer a comprehensive Rejuran experience tailored to your specific needs. Our approach includes customized formulation selection, advanced injection techniques, complementary treatment options, and dedicated international patient support. Begin your journey with a personalized consultation where our experts will assess your concerns, create a custom treatment plan, and schedule your sessions with flexibility for international visitors. As a leading aesthetic clinic in Korea, we provide exceptional care through our board-certified specialists, dedicated patient coordinators with translation services, state-of-the-art facilities in Gangnam, and comprehensive aftercare support. Experience the difference our specialized expertise makes in achieving healthier, more youthful skin through revolutionary Rejuran treatments.

Learn More about AB Plastic Surgery Korea “International Patient Support"